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Modulation of P-glycoprotein-mediated resistance by kaempferol derivatives isolated from Zingiber zerumbet

Title
Modulation of P-glycoprotein-mediated resistance by kaempferol derivatives isolated from Zingiber zerumbet
Authors
Soo Y.C.Dae S.J.Han A.-R.Jung O.J.Kwon Y.Seo E.-K.Hwa J.L.
Ewha Authors
서은경이화정권영주한아름
SCOPUS Author ID
서은경scopus; 이화정scopus; 권영주scopus; 한아름scopusscopus
Issue Date
2007
Journal Title
Phytotherapy Research
ISSN
0951-418XJCR Link
Citation
vol. 21, no. 6, pp. 565 - 569
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
This study examined the effects of the kaempferol derivatives extracted from Zingiber zerumbet on the accumulation and efflux of [3H]- daunomycin (DNM) in P-glycoprotein (P-gp) overexpressing multidrug resistant (MDR) human breast cancer cells, MCF-7/ADR. Of six kaempferol derivatives extracted from Z. zerumbet, kaempferol-3-O-methyl ether (1) and kaempferol-3,4′-O-dimethyl ether (2) showed a potent P-gp inhibitory effect as great as verapamil, a well-known P-gp inhibitor. The P-gp inhibitory activity of these two compounds was through a 3-fold increase of the level of [3H]-DNM accumulation and a decrease of P-gp-mediated efflux. These results suggest that the kaempferol derivative components of Z. zerumbet can be used as a scaffold for developing agents that reverse P-gp-mediated MDR in human cancer chemotherapy. Copyright © 2007 John Wiley & Sons, Ltd.
DOI
10.1002/ptr.2113
Appears in Collections:
약학대학 > 약학과 > Journal papers
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