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New inorganic-based drug delivery system of indole-3-acetic acid-layered metal hydroxide nanohybrids with controlled release rate

Title
New inorganic-based drug delivery system of indole-3-acetic acid-layered metal hydroxide nanohybrids with controlled release rate
Authors
Yang J.-H.Han Y.-S.Park M.Park T.Hwang S.-J.Choy J.-H.
Ewha Authors
최진호황성주양재훈
SCOPUS Author ID
최진호scopus; 황성주scopus; 양재훈scopus
Issue Date
2007
Journal Title
Chemistry of Materials
ISSN
0897-4756JCR Link
Citation
vol. 19, no. 10, pp. 2679 - 2685
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We have developed new inorganic-based drug delivery systems through the hybridization of indole-3-acetic acid (IAA) and layered metal hydroxide such as zinc basic hydroxide salt (ZBS) and zinc aluminum layered double hydroxide (ZALDH). A coprecipitation method as well as an ion-exchange route is found to be commonly effective in synthesizing both IAA-ZBS and IAA-ZALDH nanohybrids, in which the tilted bilayers of IAA are stabilized in the interlayer space of layered metal hydroxide lattice. According to the FT-IR spectroscopic analyses, IAA molecules interact more strongly with the ZBS lattice than the ZALDH one, which is due to the formation of coordination bonds between carboxyl groups of the guest species and coordinatively unsaturated Zn(OH) 3 units of the host ZBS lattice. Such an interaction gives rise to a slower release of the IAA molecules from the ZBS-based nanohybrid than from the ZALDH-based one. The present results underscore that the layered hydroxydouble salt like ZBS makes it possible to design and develop new efficient drug-delivery systems with the suspended release of guest molecules. © 2007 American Chemical Society.
DOI
10.1021/cm070259h
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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