Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김춘미 | * |
dc.contributor.author | 박혜영 | * |
dc.contributor.author | 김화정 | * |
dc.contributor.author | 이상국 | * |
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-28T12:08:40Z | - |
dc.date.available | 2016-08-28T12:08:40Z | - |
dc.date.issued | 2007 | * |
dc.identifier.issn | 0223-5234 | * |
dc.identifier.other | OAK-3898 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219841 | - |
dc.description.abstract | The substituted pyridazino[4,5-b]phenazine-5,12-diones and tri/tetra-azabenzo[a]fluorene-5,6-diones were synthesized from 6,7-dichlorophthalazine-5,8-dione and 6,7-dichloroquinoline-5,8-dione, respectively. The cytotoxic activities of the prepared compounds were evaluated by an SRB (Sulforhodamine B) assay against the following human cancer cell lines: A549 (lung), SK-OV-3 (ovarian), SK-MEL-2 (melanoma), XF 498 (CNS), and HCT 15 (colon). Almost all synthesized pyridazino[4,5-b]phenazine-5,12-diones (7a-j) presented higher cytotoxicity than that of doxorubicin (IC50 = 0.097-0.225 μM) against the cancer cell lines. In particular, the cytotoxicity of compounds 7f (R1 = Et) and 7h (R1, R2 = Me) against all human cancer cell lines examined was about 10 times higher than that of doxorubicin. However, the cytotoxicities of several synthesized azabenzo[a]fluorene-5,6-diones (12a, 12c, 12d, 12e, and 12g) against the cancer cell lines in vitro were comparable to those of doxorubicin. © 2006 Elsevier Masson SAS. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis and cytotoxicity evaluation of substituted pyridazino[4,5-b]phenazine-5,12-diones and tri/tetra-azabenzofluorene-5,6-diones | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 42 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 168 | * |
dc.relation.lastpage | 174 | * |
dc.relation.journaltitle | European Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.ejmech.2006.09.007 | * |
dc.identifier.wosid | WOS:000245248300006 | * |
dc.identifier.scopusid | 2-s2.0-33847155172 | * |
dc.author.google | Lee H.-J. | * |
dc.author.google | Kim J.S. | * |
dc.author.google | Suh M.-E. | * |
dc.author.google | Park H.J. | * |
dc.author.google | Lee S.K. | * |
dc.author.google | Rhee H.-K. | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Kim C. | * |
dc.author.google | Lee C.-O. | * |
dc.author.google | Park Choo H.-Y. | * |
dc.contributor.scopusid | 김춘미(7409876240) | * |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | * |
dc.contributor.scopusid | 김화정(56670336100) | * |
dc.contributor.scopusid | 이상국(36067620500) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118124308 | * |