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Two axes in platelet-derived growth factor signaling: Tyrosine phosphorylation and reactive oxygen species

Title
Two axes in platelet-derived growth factor signaling: Tyrosine phosphorylation and reactive oxygen species
Authors
Kang S.W.
Ewha Authors
강상원
SCOPUS Author ID
강상원scopus
Issue Date
2007
Journal Title
Cellular and Molecular Life Sciences
ISSN
1420-682XJCR Link
Citation
vol. 64, no. 5, pp. 533 - 541
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The tyrosine phosphorylation cascade is a hallmark of platelet-derived growth factor (PDGF)- induced signal transduction. The amplitude and propagation of the tyrosine phosphorylation signal relies on the balance between tyrosine kinase and tyrosine phosphatase. The tyrosine kinase is latent in the absence of stimulation, whereas the tyrosine phosphatase is highly and constitutively active. Therefore, the kinase activation should be accompanied by temporal and spatial inactivation of tyrosine phosphatase to achieve the robust amplification of tyrosine phosphorylation. For the past decade, reactive oxygen species have been receiving a great deal of attention with regard to their ability to shut down tyrosine phosphatase activities in a reversible manner. In this article, the crosstalk between tyrosine phosphorylation and reactive oxygen species in PDGF signaling is discussed. © 2007 Birkhäuser Verlag.
DOI
10.1007/s00018-007-6437-z
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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