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Synthesis and structure-activity studies of antofine analogues as potential anticancer agents

Title
Synthesis and structure-activity studies of antofine analogues as potential anticancer agents
Authors
Fu Y.Lee S.K.Min H.-Y.Lee T.Lee J.Cheng M.Kim S.
Ewha Authors
이상국
Issue Date
2007
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 17, no. 1, pp. 97 - 100
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Due to the profound cytotoxicities and interesting biochemical aspects, phenanthroindolizidine alkaloids have received an attention as potential therapeutic leads. To define the features of the molecule that are essential for cytotoxicity, we have synthesized and evaluated a series of phenanthroindolizidine alkaloid, antofine, analogues with different substituents on the phenanthrene ring. The systematic structure activity relationship studies elucidate the essential functional group requirement of phenanthrene ring, providing the basis for further development of phenanthroindolizidine alkaloids. © 2006 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2006.09.080
Appears in Collections:
약학대학 > 약학과 > Journal papers
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