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Degradation patterns of tetracycline antibiotics in reverse micelles and water

Title
Degradation patterns of tetracycline antibiotics in reverse micelles and water
Authors
Sah H.
Ewha Authors
사홍기
SCOPUS Author ID
사홍기scopus
Issue Date
2006
Journal Title
Biomedical Chromatography
ISSN
0269-3879JCR Link
Citation
vol. 20, no. 11, pp. 1142 - 1149
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The objective of this study was to determine the chemical stability of tetracycline and oxytetracycline hydrochlorides in reverse micelles. Their reverse micellar solutions were prepared using cetyltrimethylammonium bromide, water and ethyl formate. The aqueous solutions of the tetracycline antibiotics were also prepared for comparison. The reverse micellar and aqueous solutions were stored at 37°C. Samples were analyzed by high performance liquid chromatography. When evaluation was performed on an aqueous tetracycline HCl solution, its half-life was estimated to be 329 h. Its chemical stability was not improved after being dissolved in the reverse micelles, and a similar half-life of 330 h was observed. However, there were noticeable differences between the two systems in terms of degradation kinetics and degradation byproducts. On the other hand, oxytetracycline HCl was unstable in water so that its half-life was only 34 h. Very interestingly, pronounced improvement in stability was attained with the reverse micellar system: upon dissolving in the reverse micelles, its half-life was increased to 2402 h. There were also marked differences in degradation patterns and mechanisms of oxytetracycline HCl in water and the reverse micelles. Our study indicates that the reverse micellar system has potential applications in solubilizing and stabilizing oxytetracycline HCl, thereby contributing to the development of its dosage forms. Copyright © 2006 John Wiley & Sons, Ltd.
DOI
10.1002/bmc.662
Appears in Collections:
약학대학 > 약학과 > Journal papers
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