Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2016-08-28T12:08:28Z | - |
dc.date.available | 2016-08-28T12:08:28Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.other | OAK-3534 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219753 | - |
dc.description.abstract | Two types of injectable system using thermosensitive chitosan (chitosan-g-NIPAAm), hydrogel and microparticles (MPs)-embedded hydrogel were developed as drug carriers for controlled release and their pharmaceutical potentials were investigated. 5-Fluorouracil (5-FU)-loaded, biodegradable PLGA MPs were prepared by a double emulsion method and then simply mixed with an aqueous solution of thermosensitive chitosan at room temperature. All 5-FU release rates from the hydrogel matrix were faster than bovine serum albumin (BSA), possibly due to the difference in the molecular weight of the drugs. The 5-FU release profile from MPs-embedded hydrogel was shown to reduce the burst effect and exhibit nearly zero-order release behavior from the beginning of each initial stage. Thus, these MPs-embedded hydrogels, as well as thermosensitive chitosan hydrogel, have promising potential as an injectable drug carrier for pharmaceutical applications. | - |
dc.language | English | - |
dc.title | Thermosensitive chitosan as an injectable carrier for local drug delivery | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 14 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 461 | - |
dc.relation.lastpage | 465 | - |
dc.relation.journaltitle | Macromolecular Research | - |
dc.identifier.wosid | WOS:000240423300011 | - |
dc.identifier.scopusid | 2-s2.0-33748792019 | - |
dc.author.google | Bae J.W. | - |
dc.author.google | Go D.H. | - |
dc.author.google | Park K.D. | - |
dc.author.google | Lee S.J. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230118105419 | - |