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Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents

Title
Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents
Authors
Yoo B.N.Kim H.O.Moon H.R.Seol S.K.Jang S.K.Lee K.M.Jeong L.S.
Ewha Authors
이강만정낙신
SCOPUS Author ID
이강만scopus; 정낙신scopus
Issue Date
2006
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
Bioorganic and Medicinal Chemistry Letters vol. 16, no. 16, pp. 4190 - 4194
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
On the basis of potent anti-HCV activity of 2′-C-methyladenosine, novel 2′-C-hydroxymethyladenosine analogues 2a-c were synthesized from d-ribose in order to lead to favorable interaction with HCV polymerase. Among compounds tested, adenosine derivative 2a exhibited potent anti-HCV activity, indicating that the hydroxyl group of 2′-C-hydroxymethyl substituent led to favorable interaction with HCV polymerase. © 2006 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2006.05.089
Appears in Collections:
약학대학 > 약학과 > Journal papers
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