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Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents

Title
Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents
Authors
Yoo B.N.Kim H.O.Moon H.R.Seol S.K.Jang S.K.Lee K.M.Jeong L.S.
Ewha Authors
이강만정낙신
SCOPUS Author ID
이강만scopus
Issue Date
2006
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 16, no. 16, pp. 4190 - 4194
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
On the basis of potent anti-HCV activity of 2′-C-methyladenosine, novel 2′-C-hydroxymethyladenosine analogues 2a-c were synthesized from d-ribose in order to lead to favorable interaction with HCV polymerase. Among compounds tested, adenosine derivative 2a exhibited potent anti-HCV activity, indicating that the hydroxyl group of 2′-C-hydroxymethyl substituent led to favorable interaction with HCV polymerase. © 2006 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2006.05.089
Appears in Collections:
약학대학 > 약학과 > Journal papers
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