View : 15 Download: 0

The expression of VegT requires both Xenopus nodal-related and FGF signaling pathways during early Xenopus embryogenesis

Title
The expression of VegT requires both Xenopus nodal-related and FGF signaling pathways during early Xenopus embryogenesis
Authors
Kim Y.-J.Yeo C.-Y.
Ewha Authors
여창열
SCOPUS Author ID
여창열scopus
Issue Date
2006
Journal Title
Korean Journal of Genetics
ISSN
0254-5934JCR Link
Citation
vol. 28, no. 2, pp. 171 - 177
Indexed
SCOPUS WOS scopus
Abstract
Xenopus nodal-related (Xnr) proteins and FGF play crucial roles during mesoderm induction in amphibian Xenopus laevis embryos. The endogenous and ectopic Xnr-induced expression of mesodermal genes, including VegT, requires FGF signaling such that their expression is abolished when FGF signaling is inhibited. However, the molecular mechanism for the interaction between the two signaling pathways is largely unknown. In order to understand their interaction, we isolated a 2.2 kb-long DNA fragment immediately upstream of Xenopus laevis VegT transcription start site and identified a 274 bp-long fragment that requires both Xnr and FGF signaling for transcriptional activation. From this sequence we identified two regulatory elements; one was necessary for Xnr1-induced activation and the other for FGF-induced activation. Our results suggest that the expression of VegT is regulated, at least in part, by two distinct transcription factors which mediate Xnr and FGF signaling, respectively. © The Genetics Society of Korea.
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE