View : 15 Download: 0

Rotational gating mechanisms of an ion channel with a negative hydrophobic mismatch

Title
Rotational gating mechanisms of an ion channel with a negative hydrophobic mismatch
Authors
Lee K.-J.-B.
Ewha Authors
이공주복
SCOPUS Author ID
이공주복scopus
Issue Date
2006
Journal Title
Journal of the Korean Physical Society
ISSN
0374-4884JCR Link
Citation
vol. 49, no. 1, pp. 261 - 265
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
We analyze the energetics of three rotational gating mechanisms of an ion channel in the presence of a negative hydrophobic mismatch. To evaluate the free energy of the membrane deformation during the gating process, we use the continuum model imposing a strong hydrophobic interaction at the interface of the channel proteins and the nearby lipid molecules. Three gating mechanisms describe three different transitions from a conical closed state to one bottle-neck and two cylindrical open states. Differently from the situation of a positive hydrophobic mismatch, all three open states can be energetically favorable without introducing a spontaneous curvature although a quite strong surface tension of the membrane is required if the thickness change of the membrane does not cost any energy. We also discuss the effect of the thickness change of the membrane on the gating energy.
Appears in Collections:
자연과학대학 > 물리학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE