View : 55 Download: 0

Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production

Title
Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production
Authors
Han A.-R.Kang Y.-J.Windono T.Lee S.K.Seo E.-K.
Ewha Authors
이상국서은경한아름
SCOPUS Author ID
서은경scopus; 한아름scopusscopus
Issue Date
2006
Journal Title
Journal of Natural Products
ISSN
0163-3864JCR Link
Citation
vol. 69, no. 4, pp. 719 - 721
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new prenylated chalcone, 3″,3″-dimethylpyrano[3′, 4′]2,4,2′-trihydroxychalcone (1), was isolated from the heartwood of Artocarpus communis. Two flavonoid derivatives, (-)-cycloartocarpin (9) and (-)-cudraflavone A (10), were isolated as new isomers. In addition, eight known flavonoids, isobacachalcone (2), morachalcone A (3), gemichalcones B (4) and C (5), artocarpin (6), cudraflavone C (7), licoflavone C (8), and (2S)-euchrenone a7 (11), were isolated and identified from this plant for the first time. Compounds 1-4, 6, and 11 exhibited potent inhibitory activity on nitric oxide production in RAW264.7 LPS-activated mouse macrophage cells with IC 50 values of 18.8, 6.4, 16.4, 9.3, 18.7, and 12.3, μM, respectively. The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. © 2006 American Chemical Society and American Society of Pharmacognosy.
DOI
10.1021/np0600346
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE