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Synthesis and antifungal activity of 6-hydroxycinnolines

Title
Synthesis and antifungal activity of 6-hydroxycinnolines
Authors
Ryu C.-K.Lee J.Y.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2006
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 16, no. 7, pp. 1850 - 1853
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
6-Hydroxycinnolines 2 and cyclohexa-2,5-diene-1,4-dione derivatives 6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 6-Hydroxycinnolines 2 showed, in general, more potent antifungal activity against Candida species than the other cyclohexa-2,5-diene- 1,4-diones. The results suggest that 6-hydroxycinnolines would be potent antifungal agents. © 2006 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2006.01.005
Appears in Collections:
약학대학 > 약학과 > Journal papers
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