Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원기 | * |
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2016-08-28T11:08:02Z | - |
dc.date.available | 2016-08-28T11:08:02Z | - |
dc.date.issued | 2006 | * |
dc.identifier.issn | 0022-3042 | * |
dc.identifier.other | OAK-3216 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219678 | - |
dc.description.abstract | Lipid membrane peroxidation is highly associated with neuronal death in various neurodegenerative diseases including cerebral stroke. Here, we report that simvastatin decreases oxygen and glucose deprivation (OGD)/reoxygenation- evoked neuronal death by inhibiting the production and cytoxicity of 4-hydroxy-2E-nonenal (HNE), the final product of lipid peroxidation. Simvastatin markedly decreased the OGD/reoxygenation-evoked death of cortical neurons. OGD/reoxygenation increased the intracellular HNE level mostly in neuronal cells, not glial cells. Simvastatin decreased the intracellular level of HNE in neuronal cells exposed to OGD/reoxygenation. We further found that HNE induced the cytotoxicity in neuronal cells and synergistically increased the N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity. Simvastatin largely blocked the NMDA neurotoxicity potentiated by HNE. However, simvastatin did not alter the NMDA-evoked calcium influx in the absence or presence of HNE. HNE inhibited the activity of nuclear factor-kappa B (NF-κB), and the cytotoxicity of HNE was in good correlation with inactivation of NF-κB. Simvastatin reversed the inhibition of NF-κB activity induced by OGD/reoxygenation or HNE. The neuroprotection by simvastatin was significantly attenuated by various NF-κB inhibitors, implying that simvastatin inhibits the cytotoxicity of HNE at least in part by maintaining the activity of NF-κB. Further understanding of the neuroprotective mechanism of simvastatin may provide a therapeutic strategy for oxidative stress-related neurodegenerative diseases. © 2006 The Authors. | * |
dc.language | English | * |
dc.title | Simvastatin prevents oxygen and glucose deprivation/reoxygenation-induced death of cortical neurons by reducing the production and toxicity of 4-hydroxy-2E-nonenal | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 97 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 140 | * |
dc.relation.lastpage | 150 | * |
dc.relation.journaltitle | Journal of Neurochemistry | * |
dc.identifier.doi | 10.1111/j.1471-4159.2006.03715.x | * |
dc.identifier.wosid | WOS:000235986000013 | * |
dc.identifier.scopusid | 2-s2.0-33644946838 | * |
dc.author.google | Lim J.H. | * |
dc.author.google | Lee J.-C. | * |
dc.author.google | Lee Y.H. | * |
dc.author.google | Choi I.Y. | * |
dc.author.google | Oh Y.-K. | * |
dc.author.google | Kim H.-S. | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Kim W.-K. | * |
dc.contributor.scopusid | 김원기(34770946200) | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |