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Crystal structure of TM1457 from Thermotoga maritima

Title
Crystal structure of TM1457 from Thermotoga maritima
Authors
Shin D.H.Lou Y.Jancarik J.Yokota H.Kim R.Kim S.-H.
Ewha Authors
신동해
SCOPUS Author ID
신동해scopus
Issue Date
2005
Journal Title
Journal of Structural Biology
ISSN
1047-8477JCR Link
Citation
vol. 152, no. 2, pp. 113 - 117
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The crystal structure of a hypothetical protein, TM1457, from Thermotoga maritima has been determined at 2.0 Å resolution. TM1457 belongs to the DUF464 family (57 members) for which there is no known function. The structure shows that it is composed of two helices in contact with one side of a five-stranded β-sheet. Two identical monomers form a pseudo-dimer in the asymmetric unit. There is a large cleft between the first α-helix and the second β-strand. This cleft may be functionally important, since the two highly conserved motifs, GHA and VCAXV(S/T), are located around the cleft. A structural comparison of TM1457 with known protein structures shows the best hit with another hypothetical protein, Ybl001C from Saccharomyces cerevisiae, though they share low structural similarity. Therefore, TM1457 still retains a unique topology and reveals a novel fold. © 2005 Elsevier Inc. All rights reserved.
DOI
10.1016/j.jsb.2005.08.008
Appears in Collections:
약학대학 > 약학과 > Journal papers
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