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Repression of interferon-γ-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways

Title
Repression of interferon-γ-induced inducible nitric oxide synthase (iNOS) gene expression in microglia by sodium butyrate is mediated through specific inhibition of ERK signaling pathways
Authors
Park J.-S.Woo M.-S.Kim S.-Y.Kim W.-K.Kim H.-S.
Ewha Authors
김원기김희선박진선
SCOPUS Author ID
김희선scopus; 박진선scopus
Issue Date
2005
Journal Title
Journal of Neuroimmunology
ISSN
0165-5728JCR Link
Citation
vol. 168, no. 41276, pp. 56 - 64
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We have reported recently that sodium butyrate suppressed IFN-γ, but not the LPS-mediated induction of nitric oxide and TNF-α in microglia via the specific inhibition of NF-κB. In order to further determine the upstream signaling mechanism involved in the IFN-γ-specific down-regulation of iNOS by sodium butyrate in microglia, this study investigated the effect of sodium butyrate on the MAP kinase activities. Sodium butyrate significantly repressed the phosphorylation of ERK induced by IFN-γ, but had little effect on that induced by LPS. This suggests that sodium butyrate suppresses the IFN-γ-induced iNOS expression by inhibiting the ERK to NF-κB pathway. In addition, it was found that sodium butyrate suppressed the IFN-γ-induced interferon regulatory factor 1 (IRF-1) expression via the inhibition of ERK. Therefore, the ERK signaling pathway appears to play a key role in the sodium butyrate-mediated down-regulation of iNOS in the IFN-γ-stimulated microglia. © 2005 Elsevier B.V. All rights reserved.
DOI
10.1016/j.jneuroim.2005.07.003
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자연과학대학 > 화학·나노과학전공 > Journal papers
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