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Humulene derivatives from Zingiber zerumbet with the inhibitory effects on lipopolysaccharide-induced nitric oxide production

Title
Humulene derivatives from Zingiber zerumbet with the inhibitory effects on lipopolysaccharide-induced nitric oxide production
Authors
Jang D.S.Min H.-Y.Kim M.-S.Han A.-R.Windono T.Jeohn G.-H.Sam S.K.Lee S.K.Seo E.-K.
Ewha Authors
이상국서은경한아름
SCOPUS Author ID
서은경scopus; 한아름scopusscopus
Issue Date
2005
Journal Title
Chemical and Pharmaceutical Bulletin
ISSN
0009-2363JCR Link
Citation
vol. 53, no. 7, pp. 829 - 831
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new humulene sesquiterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E- humulatrien-8-one) (1) and a known compound, zerumboneoxide (2) were isolated from the rhizomes of Zingiber zerumbet (Zingiberaceae), and found to inhibit lipopolysaccharide-induced nitric oxide production in murine macrophage RAW 264.7 cells with IC50 values of 14.1 and 23.5 μM, respectively, by bioassay-guided fractionation (positive control: Nω-monomethyl-L- arginine, IC50=21.3 μM). The structure of 1 was determined by spectroscopic methods including 1D and 2D-NMR. © 2005 Pharmaceutical Society of Japan.
DOI
10.1248/cpb.53.829
Appears in Collections:
약학대학 > 약학과 > Journal papers
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