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Humulene derivatives from Zingiber zerumbet with the inhibitory effects on lipopolysaccharide-induced nitric oxide production
- Title
- Humulene derivatives from Zingiber zerumbet with the inhibitory effects on lipopolysaccharide-induced nitric oxide production
- Authors
- Jang D.S.; Min H.-Y.; Kim M.-S.; Han A.-R.; Windono T.; Jeohn G.-H.; Sam S.K.; Lee S.K.; Seo E.-K.
- Ewha Authors
- 이상국; 서은경; 한아름
- SCOPUS Author ID
- 이상국; 서은경; 한아름
- Issue Date
- 2005
- Journal Title
- Chemical and Pharmaceutical Bulletin
- ISSN
- 0009-2363
- Citation
- Chemical and Pharmaceutical Bulletin vol. 53, no. 7, pp. 829 - 831
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A new humulene sesquiterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E- humulatrien-8-one) (1) and a known compound, zerumboneoxide (2) were isolated from the rhizomes of Zingiber zerumbet (Zingiberaceae), and found to inhibit lipopolysaccharide-induced nitric oxide production in murine macrophage RAW 264.7 cells with IC50 values of 14.1 and 23.5 μM, respectively, by bioassay-guided fractionation (positive control: Nω-monomethyl-L- arginine, IC50=21.3 μM). The structure of 1 was determined by spectroscopic methods including 1D and 2D-NMR. © 2005 Pharmaceutical Society of Japan.
- DOI
- 10.1248/cpb.53.829
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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