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Induction of peripheral tolerance in dual TCR T cells: An evidence for non-dominant signaling by one TCR

Title
Induction of peripheral tolerance in dual TCR T cells: An evidence for non-dominant signaling by one TCR
Authors
Hah C.Kim M.Kim K.
Ewha Authors
김길현
Issue Date
2005
Journal Title
Journal of Biochemistry and Molecular Biology
ISSN
1225-8687JCR Link
Citation
vol. 38, no. 3, pp. 334 - 342
Indexed
SCOPUS WOS scopus
Abstract
Recently, the existence of T cells with dual T cell receptor (TCR) in the immune system is generally accepted, while it has been controversial whether signals through one TCR would affect the functions of the other. In this study T cells expressing two different TCR were obtained from cross-hybrids of LCMV and AND TCR transgenic mice specific for the gp33 and peptide fragment of PCC (fPCC), respectively. Peptide stimulation demonstrated that the dual TCR T cells functioned independently in an antigen-specific manner. To examine whether the tolerance targeted for the one TCR affects the responsiveness of the other, the cross-hybrids were treated with gp33. Although T cells from F1 mice were rendered anergenic to gp33, no functional changes to fPCC were observed in terms of cellular proliferation and IL-2 secretion, suggesting that the dual TCR T cells remained reactive to fPCC. We therefore propose that signaling through the TCR is receptor-specific and 'negative dominance' of one TCR by tolerance induction is not applicable in this dual TCR system.
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자연과학대학 > 생명과학전공 > Journal papers
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