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Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b] thiophenes

Title
Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b] thiophenes
Authors
Ryu C.-K.Lee S.-K.Han J.-Y.Jung O.-J.Lee J.Y.Jeong S.H.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2005
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 15, no. 10, pp. 2617 - 2620
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
5-Arylamino-4,7-dioxobenzo[b]thiophenes 3-6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 5-Arylamino-6-chloro-2-(methoxycarbonyl)-4,7-dioxobenzo[b]thiophenes 5 showed, in general, more potent antifungal activity against Candida species than the other 4,7-dioxobenzo[b]thiophenes 3, 4 and 6. The results suggest that 5-arylamino-4,7-dioxobenzo[b]thiophenes would be potent antifungal agents. © 2005 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2005.03.042
Appears in Collections:
약학대학 > 약학과 > Journal papers
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