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Induction of apoptosis by ginseng saponin metabolite in U937 human monocytic leukemia cells
- Induction of apoptosis by ginseng saponin metabolite in U937 human monocytic leukemia cells
- Kang K.A.; Lim H.K.; Kim S.U.; Kim Y.W.; Kim W.T.; Chung H.S.; Choo M.K.; Kim D.H.; Kim H.S.; Shim M.J.; Chung M.-H.; Hyun J.W.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Journal of Food Biochemistry
- vol. 29, no. 1, pp. 27 - 40
- SCI; SCIE; SCOPUS
- We report the cytotoxicity of the ginseng saponin metabolite, Compound K (20-0-D-glucopyranosyl-20(S)-protopanaxadiol, 1H901) on various human leukemia cell lines. Compound K had the most effect on U937, a human monocytic leukemia cell line among the tested cell lines. Compound K-treated U937 cells showed characteristics of apoptosis: an exposure of phosphatidylserine from the inner cell membrane to the outer cell membrane, the formation of apoptotic bodies and DNA fragmentation. Compound K induced apoptosis by up-regulating Box, disrupting the mitochondrial membrane potential, and by activating caspase 9 and caspase 3. Therefore, we suggest that Compound K inhibits U937 cell growth by inducing apoptosis through the up-regulation of Bax and caspase activation. © Copyright 2005, Blackwell Publishing.
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