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Induction of apoptosis by ginseng saponin metabolite in U937 human monocytic leukemia cells

Title
Induction of apoptosis by ginseng saponin metabolite in U937 human monocytic leukemia cells
Authors
Kang K.A.Lim H.K.Kim S.U.Kim Y.W.Kim W.T.Chung H.S.Choo M.K.Kim D.H.Kim H.S.Shim M.J.Chung M.-H.Hyun J.W.
Ewha Authors
김희선
SCOPUS Author ID
김희선scopus
Issue Date
2005
Journal Title
Journal of Food Biochemistry
ISSN
0145-8884JCR Link
Citation
vol. 29, no. 1, pp. 27 - 40
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We report the cytotoxicity of the ginseng saponin metabolite, Compound K (20-0-D-glucopyranosyl-20(S)-protopanaxadiol, 1H901) on various human leukemia cell lines. Compound K had the most effect on U937, a human monocytic leukemia cell line among the tested cell lines. Compound K-treated U937 cells showed characteristics of apoptosis: an exposure of phosphatidylserine from the inner cell membrane to the outer cell membrane, the formation of apoptotic bodies and DNA fragmentation. Compound K induced apoptosis by up-regulating Box, disrupting the mitochondrial membrane potential, and by activating caspase 9 and caspase 3. Therefore, we suggest that Compound K inhibits U937 cell growth by inducing apoptosis through the up-regulation of Bax and caspase activation. © Copyright 2005, Blackwell Publishing.
DOI
10.1111/j.1745-4514.2005.00001.x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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