Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2016-08-28T11:08:51Z | - |
dc.date.available | 2016-08-28T11:08:51Z | - |
dc.date.issued | 2005 | * |
dc.identifier.issn | 0145-8884 | * |
dc.identifier.other | OAK-2695 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219557 | - |
dc.description.abstract | We report the cytotoxicity of the ginseng saponin metabolite, Compound K (20-0-D-glucopyranosyl-20(S)-protopanaxadiol, 1H901) on various human leukemia cell lines. Compound K had the most effect on U937, a human monocytic leukemia cell line among the tested cell lines. Compound K-treated U937 cells showed characteristics of apoptosis: an exposure of phosphatidylserine from the inner cell membrane to the outer cell membrane, the formation of apoptotic bodies and DNA fragmentation. Compound K induced apoptosis by up-regulating Box, disrupting the mitochondrial membrane potential, and by activating caspase 9 and caspase 3. Therefore, we suggest that Compound K inhibits U937 cell growth by inducing apoptosis through the up-regulation of Bax and caspase activation. © Copyright 2005, Blackwell Publishing. | * |
dc.language | English | * |
dc.title | Induction of apoptosis by ginseng saponin metabolite in U937 human monocytic leukemia cells | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 27 | * |
dc.relation.lastpage | 40 | * |
dc.relation.journaltitle | Journal of Food Biochemistry | * |
dc.identifier.doi | 10.1111/j.1745-4514.2005.00001.x | * |
dc.identifier.wosid | WOS:000228639900003 | * |
dc.identifier.scopusid | 2-s2.0-21144448880 | * |
dc.author.google | Kang K.A. | * |
dc.author.google | Lim H.K. | * |
dc.author.google | Kim S.U. | * |
dc.author.google | Kim Y.W. | * |
dc.author.google | Kim W.T. | * |
dc.author.google | Chung H.S. | * |
dc.author.google | Choo M.K. | * |
dc.author.google | Kim D.H. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Shim M.J. | * |
dc.author.google | Chung M.-H. | * |
dc.author.google | Hyun J.W. | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |