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Identification and antibacterial activity of a new oleandomycin derivative from streptomyces antibioticus

Title
Identification and antibacterial activity of a new oleandomycin derivative from streptomyces antibioticus
Authors
Kim B.S.Oh H.Kim S.Y.Park J.A.Yoon Y.J.Lee S.K.Kim B.Y.Ahn J.S.
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2005
Journal Title
Journal of Antibiotics
ISSN
0021-8820JCR Link
Citation
vol. 58, no. 3, pp. 196 - 201
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
During the study on the oleandomycin production, we purified a new oleandomycin derivative having a macrolactone of which biosynthesis does not follow the genetic architecture of the oleandomycin PKS. The molecular formula for the compound was suggested as C35H59NO11 on the basis of the analysis of NMR and HRMS data (m/z 670.4185, Δ-1.9 mmu, calcd for C35H60NO11). 13C NMR assignments and analysis of COSY, HMBC and HMQC data suggested that the compound differs from oleandomycin by formation of the olefinic functionality resulting from the dehydration of a hydroxy group in oleandomycin. The new oleandomycin derivative has antibacterial activities similar to those of oleandomycin agaisnt Enterococcus faecalis, Bacillus subtilis and Staphylococcus aureus.
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자연과학대학 > 화학·나노과학전공 > Journal papers
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