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Auxin-induced reactive oxygen species production requires the activation of phosphatidylinositol 3-kinase

Title
Auxin-induced reactive oxygen species production requires the activation of phosphatidylinositol 3-kinase
Authors
Joo J.H.Yoo H.J.Hwang I.Lee J.S.Nam K.H.Bae Y.S.
Ewha Authors
이준승배윤수주정희
SCOPUS Author ID
이준승scopusscopus; 배윤수scopus; 주정희scopusscopus
Issue Date
2005
Journal Title
FEBS Letters
ISSN
0014-5793JCR Link
Citation
vol. 579, no. 5, pp. 1243 - 1248
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We recently reported that production of reactive oxygen species (ROS) is essential for auxin-induced gravitropic signaling. Here, we investigated the role of phosphatidylinositol 3-kinase and its product, PtdIns(3)P, in auxin-mediated ROS production and the root gravitropic response. Pretreatment with LY294002, an inhibitor of PtdIns 3-kinase activity, blocked auxin-mediated ROS generation, and reduced the sensitivity of root tissue to gravistimulation. The amount of PtdIns(3)P increased in response to auxin, and this effect was abolished by pretreatment with LY294002. In addition, sequestration of PtdIns(3)P by transient expression of the endosome binding domain in protoplasts abrogated IAA-induced ROS accumulation. These results indicate that activation of PtdIns 3-kinase and its product PtdIns(3)P are required for auxin-induced production of ROS and root gravitropism. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
DOI
10.1016/j.febslet.2005.01.018
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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