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Synthesis and antifungal activity of 5,8-quinazolinedione derivatives modified at positions 6 and 7

Title
Synthesis and antifungal activity of 5,8-quinazolinedione derivatives modified at positions 6 and 7
Authors
Ryu C.-K.Shim J.-Y.Yi Y.-J.Ik H.C.Mi J.C.Han J.-Y.Jung O.-J.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2004
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 27, no. 10, pp. 990 - 996
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
5,8-Quinazolinediones modified at positions 6 and 7 were synthesized and tested for in vitro antifungal activities against Candida species and Aspergillus niger. Most of 5,8-quinazolinediones 3-5 generally exhibited potent antifungal activity. 6-Arylamino-7-chloro-5,8-quinazolinediones (3) generally showed more potent antifungal activity than 7-arylthio-5,8-quinzolinediones (4) and 6,7-bis-(arylthio)-5,8-quinazolinediones (5).
DOI
10.1007/BF02975419
Appears in Collections:
약학대학 > 약학과 > Journal papers
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