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Lysophosphatidylcholine suppresses the expression of Phr1p and Pra1p, surface proteins involved in the morphogenesis of Candida albicans

Title
Lysophosphatidylcholine suppresses the expression of Phr1p and Pra1p, surface proteins involved in the morphogenesis of Candida albicans
Authors
Shin D.-H.Choi W.-Y.Yoo Y.-J.Kim M.-K.Choi W.
Ewha Authors
최원자
SCOPUS Author ID
최원자scopus
Issue Date
2004
Journal Title
Journal of Microbiology and Biotechnology
ISSN
1017-7825JCR Link
Citation
vol. 14, no. 4, pp. 868 - 871
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Candida albicans has become the most important human pathogen in immunocompromised patients. One important feature of the pathogenicity in C. albicans is the morphological transition from yeast to hyphae. Previously, we reported that lysophosphatidylcholine (Lyso-PC) suppressed the hyphal transition through the MAP kinase pathway (Min et al., 2001). Therefore, it should be useful to examine the unknown genes involved in the MAP kinase pathway. As a way to identify target genes of Lyso-PC in hyphal suppression, this present study exploited two-dimensional electrophoresis. It was revealed that Lyso-PC suppressed expression of Phr1p and Pra1p, surface proteins involved in the morphogenesis. © The Korean Society for Microbiology and Biotechnology.
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자연과학대학 > 생명과학전공 > Journal papers
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