View : 59 Download: 0

Chitosan sponges as tissue engineering scaffolds for bone formation

Title
Chitosan sponges as tissue engineering scaffolds for bone formation
Authors
Seol Y.-J.Lee J.-Y.Park Y.-J.Lee Y.-M.-Ku Y.Rhyu I.-C.Lee S.-J.Han S.-B.Chung C.-P.
Ewha Authors
이승진
SCOPUS Author ID
이승진scopus
Issue Date
2004
Journal Title
Biotechnology Letters
ISSN
0141-5492JCR Link
Citation
vol. 26, no. 13, pp. 1037 - 1041
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Rat calvarial osteoblasts were grown in porous chitosan sponges fabricated by freeze drying. The prepared chitosan sponges had a porous structure with a 100-200 m pore diameter, which allowed cell proliferation. Cell density, alkaline phosphatase activity and calcium deposition were monitored for up to 56 d culture. Cell numbers were 4 × 10 6 (day 1), 11 × 10 6 (day 28) and 12 × 10 6 (day 56) per g sponge. Calcium depositions were 9 (day 1), 40 (day 28) and 48 (day 56) g per sponge. Histological results corroborated that bone formation within the sponges had occurred. These results show that chitosan sponges can be used as effective scaffolding materials for tissue engineered bone formation in vitro.
DOI
10.1023/B:BILE.0000032962.79531.fd
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE