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Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation

Title
Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation
Authors
Hong S.-Y.Chung K.-H.You H.-J.Choi I.H.Chae M.J.Han J.-Y.Jung O.-J.Kang S.-J.Ryu C.-K.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2004
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 14, no. 13, pp. 3563 - 3566
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole- 4,7-diones exhibited potent antiproliferative activity. Benzimidazole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs. © 2004 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2004.04.051
Appears in Collections:
약학대학 > 약학과 > Journal papers
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