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Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation

Title: Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation

Authors: Hong S.-Y.; Chung K.-H.; You H.-J.; Choi I.H.; Chae M.J.; Han J.-Y.; Jung O.-J.; Kang S.-J.; Ryu C.-K.

Ewha Authors: 유충규

SCOPUS Author ID: 유충규

Issue Date: 2004

Journal Title: Bioorganic and Medicinal Chemistry Letters

ISSN: 0960-894X

Citation: Bioorganic and Medicinal Chemistry Letters vol. 14, no. 13, pp. 3563 - 3566

Indexed: SCIE; SCOPUS

Document Type: Article

Abstract: A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole- 4,7-diones exhibited potent antiproliferative activity. Benzimidazole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs. © 2004 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.bmcl.2004.04.051

Appears in Collections:: 약학대학 > 약학과 > Journal papers

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