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6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents

Title
6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents
Authors
Park H.J.Kim Y.-S.Kim J.S.Lee E.-J.Yi Y.-J.Hwang H.J.Suh M.-E.Ryu C.-K.Lee S.K.
Ewha Authors
유충규이상국
SCOPUS Author ID
유충규scopus
Issue Date
2004
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 14, no. 13, pp. 3385 - 3388
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A series of 6-arylamino-7-chloro-quinazoline-5,8-diones were prepared and evaluated for their in vitro cytotoxicity in cultured human cancer cell lines A549 (lung cancer), Col2 (colon cancer), and SNU-638 (stomach cancer). The preliminary structure-activity relationship has been described for providing further development of potent antitumor agents. To further investigate the cytotoxic mechanism, the effects of test compounds on DNA topoisomerase I and II activities have been assessed. © 2004 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2004.04.094
Appears in Collections:
약학대학 > 약학과 > Journal papers
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