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Suppression of ceramide-induced cell death by hepatitis C virus core protein

Title
Suppression of ceramide-induced cell death by hepatitis C virus core protein
Authors
Kim J.S.Ryu J.Hwang S.B.Lee S.Y.Choi S.Y.Park J.
Ewha Authors
이수영
SCOPUS Author ID
이수영scopus
Issue Date
2004
Journal Title
Journal of Biochemistry and Molecular Biology
ISSN
1225-8687JCR Link
Citation
vol. 37, no. 2, pp. 192 - 198
Indexed
SCOPUS WOS scopus
Abstract
The hepatitis C virus (HCV) core protein is believed to be one of viral proteins that are capable of preventing virus-infected cell death upon various stimuli. But, the effect of the HCV core protein on apoptosis that is induced by various stimuli is contradictory. We examined the possibility that the HCV core protein affects the ceramide-induced cell death in cells expressing the HCV core protein through the sphingomyelin pathway. Cell death that is induced by C2-ceramide and bacterial sphingomyelinase was analyzed in 293 cells that constitutively expressed the HCV core protein and compared with 293 cells that were stably transfected only with the expression vector. The HCV core protein inhibited the cell death that was induced by these reagents. The protective effects of the HCV core protein on ceramide-induced cell death were reflected by the reduced expression of p21WAF1/Cip1/Sid1 and the sustained expression of the Bcl-2 protein in the HCV core-expressing cells with respect to the vector-transfected cells. These results suggest that the HCV core protein in 293 cells plays a role in the modulation of the apoptotic response that is induced by ceramide. Also, the ability of the HCV core protein to suppress apoptosis might have important implications in understanding the pathogenesis of the HCV infection.
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자연과학대학 > 생명과학전공 > Journal papers
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