Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서명은 | * |
dc.contributor.author | 김화정 | * |
dc.contributor.author | 서은경 | * |
dc.contributor.author | 김진성 | * |
dc.date.accessioned | 2016-08-28T11:08:38Z | - |
dc.date.available | 2016-08-28T11:08:38Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-2096 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219416 | - |
dc.description.abstract | The 6,11-dihydro-pyridazo[2,3-b]phenazine-6,11-dione and 6,11-dihydro-pyrido[2,3-b]phenazine-6,11-dione derivatives were synthesized from 6,7-dichloro-5,8-phthalazinedione and 6,7-dichloro-5,8-quinolinedione, respectively, producing a series of new anticancer drugs. The cytotoxic activities of the prepared compounds were evaluated by a SRB (Sulforhodamine B) assay against the following tumor cell lines: A459 (human lung), SK-OV-3 (human ovarian), SK-MEL-2 (human melanoma), XF498 (human CNS), and HCT 15 (human colon). Almost all the derivatives of the 6,11-dihydro-pyridazo[2[,3-b] phenazine-6,11-dione and 6,11-dihydro-pyrido[2,3-b]phenazine-6,11-dione, tetracyclic heteroquinone analogues with four or three nitrogen atoms, exhibited excellent cytotoxicity on almost all the human tumor cell lines tested. Specifically, 6,11-dihydro-pyridazo[2,3-b]phenazine-6,11-dione (4a) exhibited potent activity against all the tumor cell lines, and in particular, its cytotoxic effect against HCT 15 (ED50=0.004 μg/mL) was 25 times greater than that of doxorubicin (ED50=0.093 μg/mL). © 2004 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis and cytotoxicity evaluation of 6,11-dihydro-pyridazo- and 6,11-dihydro-pyrido[2,3-b]phenazine-6,11-diones | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1623 | * |
dc.relation.lastpage | 1628 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.bmc.2004.01.029 | * |
dc.identifier.wosid | WOS:000220481200005 | * |
dc.identifier.scopusid | 2-s2.0-1542509347 | * |
dc.author.google | Lee H.-J. | * |
dc.author.google | Kim J.S. | * |
dc.author.google | Park S.-Y. | * |
dc.author.google | Suh M.-E. | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Lee C.-O. | * |
dc.contributor.scopusid | 서명은(7103253844) | * |
dc.contributor.scopusid | 김화정(56670336100) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 김진성(57216912267) | * |
dc.date.modifydate | 20240423081003 | * |