Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 유충규 | - |
dc.date.accessioned | 2016-08-28T11:08:37Z | - |
dc.date.available | 2016-08-28T11:08:37Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0031-7012 | - |
dc.identifier.other | OAK-2052 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219406 | - |
dc.description.abstract | Several compounds with the backbone of 1,4-naphthoquinone chemical structure have been reported to display antiplatelet and antithrombotic activities, indicating that this congener compound may be a new source in the antithrombotic drug development. In the present study, the possible antiplatelet activity and antithrombotic efficacy of J78 (2-chloro-3-[2′- bromo, 4′-fluorophenyl]-amino-8-hydroxy-1,4-naphthoquinone), a newly synthesized 1,4-naphthoquinone derivative, were examined. Orally administered J78 (50, 100 mg/kg) dose dependently protected mice against the collagen + epinephrine-induced thromboembolic death. Orally administered J78 also significantly inhibited the ADP- and collagen-induced rat platelet aggregation ex vivo, with inhibition values of 44 and 40%, respectively. J78 inhibited the collagen-, arachidonic acid- and thrombin-induced human platelet aggregation concentration dependently in vitro, with IC 50 values of 7.8 ± 0.4, 10.1 ± 0.4 and 18.4 ± 2.0 μmol/l, respectively. It was also active in inhibiting Ca 2+ ionophore, A23187-induced platelet aggregation, suggesting that J78 may have an inhibitory effect on Ca 2+ mobilization. J78, however, did not alter coagulation parameters such as activated partial thromboplastin time and prothrombin time in human plasma. Taken together, these results suggest that J78 may be a promising antithrombotic agent, and its antithrombotic activity may be due to antiplatelet rather than anticoagulation activity. Copyright © 2004 S. Karger AG, Basel. | - |
dc.language | English | - |
dc.title | Inhibitory effects of J78, a newly synthesized 1,4-naphthoquinone derivative, on experimental thrombosis and platelet aggregation | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 70 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 195 | - |
dc.relation.lastpage | 200 | - |
dc.relation.journaltitle | Pharmacology | - |
dc.identifier.doi | 10.1159/000075548 | - |
dc.identifier.wosid | WOS:000220027600004 | - |
dc.identifier.scopusid | 2-s2.0-1542343907 | - |
dc.author.google | Jin Y.-R. | - |
dc.author.google | Ryu C.-K. | - |
dc.author.google | Moon C.-K. | - |
dc.author.google | Cho M.-R. | - |
dc.author.google | Yun Y.-P. | - |
dc.contributor.scopusid | 유충규(15846918400) | - |
dc.date.modifydate | 20170901081001 | - |