Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤영대 | - |
dc.date.accessioned | 2016-08-28T11:08:34Z | - |
dc.date.available | 2016-08-28T11:08:34Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | OAK-1773 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219363 | - |
dc.description.abstract | IL-23 is a heterodimeric cytokine consisting of p19 and the p40 subunit of IL-12. IL-23 has been shown to possess IL-12-like biological activities, but is different in its capacity to stimulate memory T cells in vitro. In this study, we investigated whether IL-23 could influence envelope protein 2 (E2)-specific cell-mediated immunity induced by immunization of hepatitis C virus E2 DNA. We found that IL-23 induced long-lasting Th1 and CTL immune responses to E2, which are much stronger than IL-12-mediated immune responses. Interestingly, IL-23N220L, an N-glycosylation mutant showing reduced expression of excess p40 without changing the level of IL-23, exhibited a higher ratio of IFN-γ- to IL-4-producing CD4 + T cell frequency than did wild-type IL-23, suggesting a negative regulatory effect of p40 on Th1-prone immune response induced by IL-23. These data suggest that IL-23, particularly IL-23N220L, would be an effective adjuvant of DNA vaccine for the induction of durable Ag-specific T cell immunity. | - |
dc.language | English | - |
dc.title | IL-23 Induces Stronger Sustained CTL and Th1 Immune Responses Than IL-12 in Hepatitis C Virus Envelope Protein 2 DNA Immunization | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 172 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 525 | - |
dc.relation.lastpage | 531 | - |
dc.relation.journaltitle | Journal of Immunology | - |
dc.identifier.wosid | WOS:000187427700065 | - |
dc.identifier.scopusid | 2-s2.0-0346734181 | - |
dc.author.google | Ha S.-J. | - |
dc.author.google | Kim D.-J. | - |
dc.author.google | Baek K.-H. | - |
dc.author.google | Yun Y.-D. | - |
dc.author.google | Sung Y.-C. | - |
dc.contributor.scopusid | 윤영대(7201731033) | - |
dc.date.modifydate | 20200901081003 | - |