Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이종란 | - |
dc.date.accessioned | 2016-08-28T11:08:34Z | - |
dc.date.available | 2016-08-28T11:08:34Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | OAK-1772 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219362 | - |
dc.description.abstract | To extend our previous report, which showed the production of the reactive oxygen species (ROS) after the CD40 ligation in the B cells, we further examined the possible mechanisms for ROS production and the involvement of CD40-induced ROS in p38 activation. Our research shows that the stimulation of WEHI 231 B lymphomas with anti-CD40 induced ROS production and p38 activation. An antioxidant N-acetyl-L-cysteine or an inhibitor for NADPH oxidase blocked both of these, but the inhibitors for 5-lipoxygenase did not. We also show that the treatment of cells with inhibitors for the phosphatidylinositol 3-kinase (PI3-K) interfered with the CD40-induced ROS production and p38 activation. In addition, when overexpressed with a dominant negative form of either Rac1 (N17Rac1) or the TNFR-associated factor (TRAF) 3, the WEHI 231 B cells did not show a full response to the CD40 stimulation to produce ROS. Molecular association studies further revealed that the TRAF3 association with p40 phox, a cytosolic subunit of NADPH oxidase and p85 (a subunit of PI3-K), may possibly be responsible for the production of ROS by CD40 stimulation in WEHI 231 B cells. Collectively, these data suggest that the CD40-induced ROS production by NADPH oxidase in WEHI 231 requires the role of TRAF3, as well as activities of PI3-K and Rac1. | - |
dc.language | English | - |
dc.title | Role of TNF Receptor-Associated Factor 3 in the CD40 Signaling by Production of Reactive Oxygen Species through Association with p40 phox, a Cytosolic Subunit of Nicotinamide Adenine Dinucleotide Phosphate Oxidase | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 172 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 231 | - |
dc.relation.lastpage | 239 | - |
dc.relation.journaltitle | Journal of Immunology | - |
dc.identifier.wosid | WOS:000187427700032 | - |
dc.identifier.scopusid | 2-s2.0-0347994954 | - |
dc.author.google | Ha Y.J. | - |
dc.author.google | Lee J.R. | - |
dc.contributor.scopusid | 이종란(37960967100) | - |
dc.date.modifydate | 20230411105011 | - |