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Synthesis of Novel Lysophosphatidylcholine Analogues Using Serine as Chiral Template

Title
Synthesis of Novel Lysophosphatidylcholine Analogues Using Serine as Chiral Template
Authors
Kim Y.-A.Chung H.-M.Park J.-S.Choi W.Min J.Park N.-H.Kim K.-H.Jhon G.-J.Han S.-Y.
Ewha Authors
전길자최원자한소엽
SCOPUS Author ID
전길자scopus; 최원자scopus; 한소엽scopus
Issue Date
2003
Journal Title
Journal of Organic Chemistry
ISSN
0022-3263JCR Link
Citation
vol. 68, no. 26, pp. 10162 - 10165
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Four novel lysophosphatidylcholine (lysoPC) analogues, (S)-N-stearoyl-O-phosphocholineserine methyl ester [(S)-1a], (R)-1-lyso-2-stearoylamino-2-deoxy-sn-glycero-3-phosphatidylcholine [(R)-2a], (R)-N-stearoyl-O-phosphocholineserine methyl ester [(R)-1b], and (S)-1-lyso-2-stearoyl-amino-2-deoxy-sn-glycero-3-phosphatidylcholine [(S)-2b], were synthesized starting from serine as a chiral template. These synthetic compounds exhibited greatly enhanced hyphal transition inhibitory activity in Candida as compared to the natural lysoPC.
DOI
10.1021/jo034969s
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자연과학대학 > 화학·나노과학전공 > Journal papers
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