Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김화정 | * |
dc.contributor.author | 배윤수 | * |
dc.date.accessioned | 2016-08-28T11:08:33Z | - |
dc.date.available | 2016-08-28T11:08:33Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-1761 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219355 | - |
dc.description.abstract | In addition to inhibiting matrix metalloproteinases, tissue inhibitor of metalloproteinase-1 (TIMP-1) is involved in the regulation of cell growth and survival. To determine its mechanism of action, we investigated effects of TIMP-1 on cell proliferation and survival and signaling pathways induced by TIMP-1 in the human breast carcinoma T-47D cell line. Treatment of T-47D cells with TIMP-1 strongly inhibited apoptosis induced by serum deprivation, but did not affect cell proliferation. TIMP-1 induced phosphorylation of Akt and extracellular signal-regulated protein kinases (ERKs), but pertussis toxin and specific inhibitors of Src family tyrosine kinases, protein tyrosine kinases, and phosphatidylinositol-3 kinase (PI3 kinase) blocked the ability of TIMP-1 to activate Akt and ERKs as well as the anti-apoptotic effect of TIMP-1. We found that TIMP-1 enhanced the kinase activities of c-Src and PI3 kinase and that this enhancement was inhibited by pertussis toxin. Inhibition of ERK activation, however, resulted in a slight decrease of the TIMP-1-induced anti-apoptotic effect. These findings demonstrate that the ability of TIMP-1 to inhibit apoptosis in T-47D cells is mediated by the sequential activation of pertussis toxin-sensitive G protein, c-Src, PI3 kinase, and Akt. © 2003 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 312 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1196 | * |
dc.relation.lastpage | 1201 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2003.11.050 | * |
dc.identifier.wosid | WOS:000187252300050 | * |
dc.identifier.scopusid | 2-s2.0-0345357726 | * |
dc.author.google | Lee S.-J. | * |
dc.author.google | Yoo H.J. | * |
dc.author.google | Bae Y.S. | * |
dc.author.google | Kim H.-J. | * |
dc.author.google | Lee S.-T. | * |
dc.contributor.scopusid | 김화정(56670336100) | * |
dc.contributor.scopusid | 배윤수(15031067200) | * |
dc.date.modifydate | 20240415133331 | * |