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Cell Cycle Dysregulation Induced by Cytoplasm of Lactococcus lactis ssp. lactis in SNUC2A, a Colon Cancer Cell Line

Title
Cell Cycle Dysregulation Induced by Cytoplasm of Lactococcus lactis ssp. lactis in SNUC2A, a Colon Cancer Cell Line
Authors
Kim J.Y.Woo H.J.Kim Y.-S.Kim K.H.Lee H.J.
Ewha Authors
김영석
SCOPUS Author ID
김영석scopus
Issue Date
2003
Journal Title
Nutrition and Cancer
ISSN
0163-5581JCR Link
Citation
vol. 46, no. 2, pp. 197 - 201
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The anticancer effect of cytoplasmic fraction from Lactococcus lactis ssp. lactis, which had showed strong antiproliferative activity against SNUC2A human colon cancer cell line in the previous study, was investigated. The proliferation of SNUC2A was inhibited by the treatment with cytoplasmic fraction of Lactococcus lactis ssp. lactis in a dose-dependent and partially reversible manner. After exposure to the cytoplasmic fraction of Lc. lactis for 72 h, strong antiproliferative activity was efficiently induced through S-phase accumulation in SNUC2A cells. Analysis of cell cycle regulatory proteins demonstrated that the cytoplasmic fraction enhanced the levels of p21 CIP1 and cyclin A, decreased cyclin E protein, and slightly reduced the activity of cyclin-dependent kinase 2 (CDK2).
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엘텍공과대학 > 식품공학전공 > Journal papers
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