Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이승진 | - |
dc.date.accessioned | 2016-08-28T11:08:30Z | - |
dc.date.available | 2016-08-28T11:08:30Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0932-0113 | - |
dc.identifier.other | OAK-1687 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219323 | - |
dc.description.abstract | Praziquantel is rapidly absorbed and secreted; and thus fractional doses are recommended for the treatment of cestode and trematode infections. In the present study, we developed a new praziquantel tablet formula allowing sustained-release (SRP). In vitro dissolution of SRP tablets showed that praziquantel at 300 mg/tablet combined with hydroxypropyl methylcellulose dissolved completely at a constant rate over 10 h, whereas the conventional praziquantel tablet (PZQ) was only 40% dissolved. Pharmacokinetic studies in dogs confirmed that SRP was absorbed more slowly than PZQ. The mean value of the area under the concentration/time curve from 0 h to the final observation time, the maximum concentration in serum, and the time of maximum concentration in serum for SRP were 3,471,500 ng/min for 0.25 ml, 10,300 ng for 0.25 ml, and 192 min, while the values for PZQ were 688,600 ng/min for 0.25 ml, 2,500 ng for 0.25 ml, and 135 min. The cure rate in dogs with a heavy infection (500 metacercariae) treated with a single dose of SRP (150 mg/tablet) at 50 mg/kg was 80%, while in dogs treated with a single dose of SRP (300 mg/tablet) at 30 mg/kg it was 60%, and the cure rate with PZQ was 20%. In each case, the egg reduction rate was similar (over 90%). No abnormal liver functions or hepatic or renal pathologies were observed in dogs administered with SRP at 30 mg/kg. The SRP tablet showed sustained release and slow absorption; and it had an improved anthelmintic efficacy against Clonorchis sinensis in experimental dogs, compared with conventional praziquantel. | - |
dc.language | English | - |
dc.title | Sustained-release praziquantel tablet: Pharmacokinetics and the treatment of clonorchiasis in beagle dogs | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 91 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 316 | - |
dc.relation.lastpage | 320 | - |
dc.relation.journaltitle | Parasitology Research | - |
dc.identifier.doi | 10.1007/s00436-003-0958-7 | - |
dc.identifier.wosid | WOS:000186094000009 | - |
dc.identifier.scopusid | 2-s2.0-0242266127 | - |
dc.author.google | Hong S.-T. | - |
dc.author.google | Lee S.H. | - |
dc.author.google | Lee S.-J. | - |
dc.author.google | Kho W.-G. | - |
dc.author.google | Lee M. | - |
dc.author.google | Li S. | - |
dc.author.google | Chung B.-S. | - |
dc.author.google | Seo M. | - |
dc.author.google | Choi M.-H. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.date.modifydate | 20230118105419 | - |