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Synthesis and biological properties of 4-substituted quinolin-2(1H)-one analogues

Title
Synthesis and biological properties of 4-substituted quinolin-2(1H)-one analogues
Authors
Jung J.-C.Oh S.Kim W.-K.Park W.-K.Kong J.Y.Park O.-S.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2003
Journal Title
Journal of Heterocyclic Chemistry
ISSN
0022-152XJCR Link
Citation
vol. 40, no. 4, pp. 617 - 623
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A variety of 4-substituted quinolin-2(1H)-ones were prepared and evaluated for N-methyl-D-aspartate (NMDA) receptor binding site activity and their abilities to inhibit neurotoxicity. The 4-(2-carbethoxyethanamino)- 7-chloro-3-nitroquinolin-2(1H)-one (9b) exhibited favorable NMDA receptor binding site activity and 7-chloro-4-(benzylamino)-3- nitroquinolin-2(1H)-one (9c) showed the most potent neurotoxicity among them. The synthetic strategies involve the use of well known keto ester condensation and reductive ring cyclization of intermediates (2a-d) to afford 4-substituted quinolin-2(1H)-ones.
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의학전문대학원 > 의학과 > Journal papers
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