Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2016-08-28T11:08:28Z | - |
dc.date.available | 2016-08-28T11:08:28Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0022-152X | * |
dc.identifier.other | OAK-1621 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219295 | - |
dc.description.abstract | A variety of 4-substituted quinolin-2(1H)-ones were prepared and evaluated for N-methyl-D-aspartate (NMDA) receptor binding site activity and their abilities to inhibit neurotoxicity. The 4-(2-carbethoxyethanamino)- 7-chloro-3-nitroquinolin-2(1H)-one (9b) exhibited favorable NMDA receptor binding site activity and 7-chloro-4-(benzylamino)-3- nitroquinolin-2(1H)-one (9c) showed the most potent neurotoxicity among them. The synthetic strategies involve the use of well known keto ester condensation and reductive ring cyclization of intermediates (2a-d) to afford 4-substituted quinolin-2(1H)-ones. | * |
dc.language | English | * |
dc.title | Synthesis and biological properties of 4-substituted quinolin-2(1H)-one analogues | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 40 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 617 | * |
dc.relation.lastpage | 623 | * |
dc.relation.journaltitle | Journal of Heterocyclic Chemistry | * |
dc.identifier.wosid | WOS:000185411500010 | * |
dc.identifier.scopusid | 2-s2.0-0141842657 | * |
dc.author.google | Jung J.-C. | * |
dc.author.google | Oh S. | * |
dc.author.google | Kim W.-K. | * |
dc.author.google | Park W.-K. | * |
dc.author.google | Kong J.Y. | * |
dc.author.google | Park O.-S. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |