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Peroxiredoxins in breast carcinoma

Title
Peroxiredoxins in breast carcinoma
Authors
Karihtala P.Mantyniemi A.Kang S.W.Kinnula V.L.Soini Y.
Ewha Authors
강상원
SCOPUS Author ID
강상원scopus
Issue Date
2003
Journal Title
Clinical Cancer Research
ISSN
1078-0432JCR Link
Citation
vol. 9, no. 9, pp. 3418 - 3424
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose: Peroxiredoxins (Prxs) are a novel group of peroxidases containing high antioxidant efficiency and some of them having also effects on cell differentiation and apoptosis. The mammalian Prx family has six distinct members located in various subcellular locations, including peroxisomes and mitochondria, places where oxidative stress is most evident. Experimental Design: We examined immunohistochemically a large set of samples from patients with breast carcinoma and investigated associations with parameters such as tumor-node-metastasis classification, hormone receptor status, and patient survival. Three biopsies of healthy breast tissue were used as controls. Results: Expression of peroxiredoxins I, III, IV, and V was found in ≥80% of cases, whereas the expression of Prx II and VI was less frequent. Increased expression of Prx III was found to associate with the presence of progesterone (P = 0.02) and estrogen (P = 0.03) receptors, and Prxs IV (P = 0.009) and VI (P = 0.04) were overexpressed in progesterone receptor positive cases. Prx V was the only isoform that associated with items of tumor-node-metastasis classification, it was connected to a larger tumor size (P = 0.05) and positive lymph node status (P = 0.04). Prx V positivity was also connected with shorter survival (P = 0.04), whereas Prxs III (P = 0.002) and IV (P = 0.02) were related to better prognosis, probably resulting from their connection with a positive hormone receptor status. Conclusions: In conclusion, we found that expression of peroxiredoxins, especially III, IV and V, is increased in breast malignancy, suggesting the induction of Prxs as response to increased production of reactive oxygen species in carcinomatous tissue.
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자연과학대학 > 생명과학전공 > Journal papers
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