View : 43 Download: 0

Synthesis and antifungal activity of 6-arylthio-/6-arylamino-4,7-dioxobenzothiazoles

Title
Synthesis and antifungal activity of 6-arylthio-/6-arylamino-4,7-dioxobenzothiazoles
Authors
Ryu C.-K.Choi K.U.Shim J.-Y.You H.-J.Choi I.H.Chae M.J.
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2003
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
vol. 11, no. 18, pp. 4003 - 4008
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
6-Arylthio-/6-arylamino-4,7-dioxobenzothiazoles were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. 6-Arylamino-4,7-dioxobenzothiazoles 5 and 6 showed, in general, more potent antifungal activity than 6-arylthio-4,7-dioxobenzothiazoles 3 and 4. The 6-arylamino-substituted compounds 5 and 6 exhibited the greatest activity. In contrast, 6-arylthio-, 2-/5-methyl- or 5-methoxy-moieties of compounds 3-4 did not improve their antifungal activity significantly. The results of this study suggest that 6-arylamino-4,7-dioxobenzothiazoles would be potent antifungal agents. © 2003 Elsevier Ltd. All rights reserved.
DOI
10.1016/S0968-0896(03)00390-0
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE