Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승진 | - |
dc.contributor.author | 정낙신 | - |
dc.date.accessioned | 2016-08-28T11:08:17Z | - |
dc.date.available | 2016-08-28T11:08:17Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.other | OAK-1387 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219177 | - |
dc.description.abstract | Several 3′-fluoro analogues, 1a, 1b, and 1c of selective and potent adenosine A3 receptor agonist, Cl-IB-MECA were synthesized from D-xylose via highly regioselective opening of lyxo-epoxides, 8a and 8b with fluoride anion. Compared to the high binding affinity of Cl-IB-MECA to the A3 adenosine receptor, the corresponding 3′-fluoro derivative showed remarkably decreased binding affinity, indicating that 3′-hydroxyl group acts as hydrogen bonding acceptor, not hydrogen bonding donor like fluorine atom in binding to the A3 adenosine receptor. © 2003 Elsevier Science Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Design, synthesis and binding affinity of 3′-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 13 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 817 | - |
dc.relation.lastpage | 820 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | - |
dc.identifier.doi | 10.1016/S0960-894X(03)00027-1 | - |
dc.identifier.wosid | WOS:000181563500009 | - |
dc.identifier.scopusid | 2-s2.0-0037430454 | - |
dc.author.google | Lim M.H. | - |
dc.author.google | Kim H.O. | - |
dc.author.google | Moon H.R. | - |
dc.author.google | Lee S.J. | - |
dc.author.google | Chun M.W. | - |
dc.author.google | Gao Z.-G. | - |
dc.author.google | Melman N. | - |
dc.author.google | Jacobson K.A. | - |
dc.author.google | Kim J.H. | - |
dc.author.google | Jeong L.S. | - |
dc.contributor.scopusid | 이승진(57196249292) | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.date.modifydate | 20230118105419 | - |