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A DNA strand-nicking principle of a higher plant, Caesalpinia sappan

Title
A DNA strand-nicking principle of a higher plant, Caesalpinia sappan
Authors
Mar W.Lee H.-T.Je K.-H.Choi H.-Y.Seo E.-K.
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2003
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 26, no. 2, pp. 147 - 150
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
To find anticancer agents from higher plants, DNA strand-scission assay method was employed for bioassay-guided fractionation as well as for screening the crude extracts. During the screening, an ethyl acetate extracts of the heartwood of Caesalpinia sappan L. (Leguminosae) exhibited potent DNA strand-scission activity. Therefore, the ethyl acetate extracts of the dried heartwood of C. sappan was subjected to the bioassay-guided fractionation, which led to the isolation of a known compound, brazilin (1) as the active constituent. In addition, caesalpine J (2) was also isolated as an inactive constituent.
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약학대학 > 약학과 > Journal papers
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