Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이공주 | - |
dc.date.accessioned | 2016-08-28T11:08:08Z | - |
dc.date.available | 2016-08-28T11:08:08Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.other | OAK-1255 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219098 | - |
dc.description.abstract | Hypoxia-inducible factor 1 (HIF-1) plays a central role in cellular adaptation to changes in oxygen availability. Recently, prolyl hydroxylation was identified as a key regulatory event that targets the HIF-1α subunit for proteasomal degradation via the pVHL ubiquitination complex. In this report, we reveal an important function for ARD1 in mammalian cells as a protein acetyltransferase by direct binding to HIF-1α to regulate its stability. We present further evidence showing that ARD1-mediated acetylation enhances interaction of HIF-1α with pVHL and HIF-1α ubiquitination, suggesting that the acetylation of HIF-1α by ARD1 is critical to proteasomal degradation. Therefore, we have concluded that the role of ARD1 in the acetylation of HIF-1α provides a key regulatory mechanism underlying HIF-1α stability. | - |
dc.language | English | - |
dc.title | Regulation and destabilization of HIF-1α by ARD1-mediated acetylation | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 111 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 709 | - |
dc.relation.lastpage | 720 | - |
dc.relation.journaltitle | Cell | - |
dc.identifier.doi | 10.1016/S0092-8674(02)01085-1 | - |
dc.identifier.wosid | WOS:000179594500012 | - |
dc.identifier.scopusid | 2-s2.0-18744375998 | - |
dc.author.google | Jeong J.-W. | - |
dc.author.google | Bae M.-K. | - |
dc.author.google | Ahn M.-Y. | - |
dc.author.google | Kim S.-H. | - |
dc.author.google | Sohn T.-K. | - |
dc.author.google | Bae M.-H. | - |
dc.author.google | Yoo M.-A. | - |
dc.author.google | Song E.J. | - |
dc.author.google | Lee K.-J. | - |
dc.author.google | Kim K.-W. | - |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | - |
dc.date.modifydate | 20230208115507 | - |