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Structural determination of hexadecanoic lysophosphatidylcholine regioisomers by fast atom bombardment tandem mass spectrometry

Title
Structural determination of hexadecanoic lysophosphatidylcholine regioisomers by fast atom bombardment tandem mass spectrometry
Authors
Hong J.Kim Y.H.Gil J.H.Cho K.Jung J.H.Han S.-Y.
Ewha Authors
한소엽
SCOPUS Author ID
한소엽scopus
Issue Date
2002
Journal Title
Rapid Communications in Mass Spectrometry
ISSN
0951-4198JCR Link
Citation
vol. 16, no. 22, pp. 2089 - 2093
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The structural determination of sn-1 and sn-2 hexadecanoic lysophosphatidylcholine (LPC) regioisomers was carried out using fast atom bombardment tandem mass spectrometry (FAB-MS/MS). The collision-induced dissociation (CID) of protonated and sodiated molecules produced diverse product ions due mainly to charge remote fragmentations. Based on the information obtained from the CID spectra of protonated and sodiated molecules, sn-1 and sn-2 hexadecanoic LPC isomers could be discriminated. Especially, the abundance ratio of the diagnostic ion pair [m/z 224/226] in the CID spectra of [M + H]+ ions was shown to be greatly different. Moreover, the cid-ms/ms spectra of sodium-adducted molecules for hexadecanoic LPC isomers showed characteristic product ions such as [M + Na - 103]+, [M + Na - 85]+, and [M + Na - 59]+, by which their regiospecificity can be differentiated. Copyright © 2002 John Wiley & Sons, Ltd.
DOI
10.1002/rcm.835
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자연과학대학 > 화학·나노과학전공 > Journal papers
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