Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-28T11:08:07Z | - |
dc.date.available | 2016-08-28T11:08:07Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.other | OAK-1233 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219086 | - |
dc.description.abstract | The inhibitors of prostaglandin biosynthesis and nitric oxide production have been considered as potential anti-inflammatory and cancer chemopreventive agents. In this study, we evaluated approximately 170 methanol extracts of natural products including Korean herbal medicines for the inhibition of prostaglandin E2 production (for COX-2 inhibitors) and nitric oxide formation (for iNOS inhibitors) in lipopolysaccharide (LPS)-induced mouse macrophages RAW264.7 cells. As a result, several extracts such as Aristolochia debilis, Cinnamomum cassia, Cinnamomum loureirii, Curcuma zedoaria, Eugenia caryophyllata, Pterocarpus santalius, Rehmania glutinosa and Tribulus terrestris showed potent inhibition of COX-2 activity (>80% inhibition at the test concentration of 10 μg/ml). In addition, the extracts of A. debilis, Caesalpinia sappan, Curcuma longa, C. zedoaria, Daphne genkwa and Morus alba were also considered as potential inhibitors of iNOS activity (>70% inhibition at the test concentration of 10 μg/ml). These active extracts mediating COX-2 and iNOS inhibitory activities are warranted for further elucidation of active principles for development of new cancer chemopreventive and/or anti-inflammatory agents. © 2002 Elsevier Science Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells | - |
dc.type | Article | - |
dc.relation.issue | 1-2 | - |
dc.relation.volume | 83 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 153 | - |
dc.relation.lastpage | 159 | - |
dc.relation.journaltitle | Journal of Ethnopharmacology | - |
dc.identifier.doi | 10.1016/S0378-8741(02)00205-2 | - |
dc.identifier.wosid | WOS:000179153700024 | - |
dc.identifier.scopusid | 2-s2.0-0036877020 | - |
dc.author.google | Hong C.H. | - |
dc.author.google | Hur S.K. | - |
dc.author.google | Oh O.-J. | - |
dc.author.google | Kim S.S. | - |
dc.author.google | Nam K.A. | - |
dc.author.google | Lee S.K. | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |