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An immune-responsive Serpin regulates the melanization cascade in Drosophila

Title
An immune-responsive Serpin regulates the melanization cascade in Drosophila
Authors
De Gregorio E.Han S.-J.Lee W.-J.Baek M.-J.Osaki T.Kawabata S.-I.Lee B.-L.Iwanaga S.Lemaitre B.Brey P.T.
Ewha Authors
이원재
Issue Date
2002
Journal Title
Developmental Cell
ISSN
1534-5807JCR Link
Citation
vol. 3, no. 4, pp. 581 - 592
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
In arthropods, the melanization reaction is associated with multiple host defense mechanism leading to the sequestration and killing of invading microorganisms. Arthropod melanization is controlled by a cascade of serine proteases that ultimately activates the enzyme prophenoloxidase (PPO), which, in turn, catalyzes the synthesis of melanin. Here we report the biochemical and genetic characterization of a Drosophila serine protease inhibitor protein, Serpin-27A, which regulates the melanization cascade through the specific inhibition of the terminal protease prophenoloxidase-activating enzyme. Our data demonstrate that Serpin-27A is required to restrict the phenoloxidase activity to the site of injury or infection, preventing the insect from excessive melanization.
DOI
10.1016/S1534-5807(02)00267-8
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일반대학원 > 바이오융합과학과 > Journal papers
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