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An immune-responsive Serpin regulates the melanization cascade in Drosophila

Title
An immune-responsive Serpin regulates the melanization cascade in Drosophila
Authors
De Gregorio E.Han S.-J.Lee W.-J.Baek M.-J.Osaki T.Kawabata S.-I.Lee B.-L.Iwanaga S.Lemaitre B.Brey P.T.
Ewha Authors
이원재
Issue Date
2002
Journal Title
Developmental Cell
ISSN
1534-5807JCR Link
Citation
Developmental Cell vol. 3, no. 4, pp. 581 - 592
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
In arthropods, the melanization reaction is associated with multiple host defense mechanism leading to the sequestration and killing of invading microorganisms. Arthropod melanization is controlled by a cascade of serine proteases that ultimately activates the enzyme prophenoloxidase (PPO), which, in turn, catalyzes the synthesis of melanin. Here we report the biochemical and genetic characterization of a Drosophila serine protease inhibitor protein, Serpin-27A, which regulates the melanization cascade through the specific inhibition of the terminal protease prophenoloxidase-activating enzyme. Our data demonstrate that Serpin-27A is required to restrict the phenoloxidase activity to the site of injury or infection, preventing the insect from excessive melanization.
DOI
10.1016/S1534-5807(02)00267-8
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일반대학원 > 바이오융합과학과 > Journal papers
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