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dc.contributor.author이원재-
dc.date.accessioned2016-08-28T11:08:06Z-
dc.date.available2016-08-28T11:08:06Z-
dc.date.issued2002-
dc.identifier.issn1534-5807-
dc.identifier.otherOAK-1205-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/219070-
dc.description.abstractIn arthropods, the melanization reaction is associated with multiple host defense mechanism leading to the sequestration and killing of invading microorganisms. Arthropod melanization is controlled by a cascade of serine proteases that ultimately activates the enzyme prophenoloxidase (PPO), which, in turn, catalyzes the synthesis of melanin. Here we report the biochemical and genetic characterization of a Drosophila serine protease inhibitor protein, Serpin-27A, which regulates the melanization cascade through the specific inhibition of the terminal protease prophenoloxidase-activating enzyme. Our data demonstrate that Serpin-27A is required to restrict the phenoloxidase activity to the site of injury or infection, preventing the insect from excessive melanization.-
dc.languageEnglish-
dc.titleAn immune-responsive Serpin regulates the melanization cascade in Drosophila-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume3-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage581-
dc.relation.lastpage592-
dc.relation.journaltitleDevelopmental Cell-
dc.identifier.doi10.1016/S1534-5807(02)00267-8-
dc.identifier.wosidWOS:000178629300015-
dc.identifier.scopusid2-s2.0-18644376155-
dc.author.googleDe Gregorio E.-
dc.author.googleHan S.-J.-
dc.author.googleLee W.-J.-
dc.author.googleBaek M.-J.-
dc.author.googleOsaki T.-
dc.author.googleKawabata S.-I.-
dc.author.googleLee B.-L.-
dc.author.googleIwanaga S.-
dc.author.googleLemaitre B.-
dc.author.googleBrey P.T.-
dc.date.modifydate20160429000000-
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일반대학원 > 바이오융합과학과 > Journal papers
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