Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이원재 | - |
dc.date.accessioned | 2016-08-28T11:08:06Z | - |
dc.date.available | 2016-08-28T11:08:06Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1534-5807 | - |
dc.identifier.other | OAK-1205 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219070 | - |
dc.description.abstract | In arthropods, the melanization reaction is associated with multiple host defense mechanism leading to the sequestration and killing of invading microorganisms. Arthropod melanization is controlled by a cascade of serine proteases that ultimately activates the enzyme prophenoloxidase (PPO), which, in turn, catalyzes the synthesis of melanin. Here we report the biochemical and genetic characterization of a Drosophila serine protease inhibitor protein, Serpin-27A, which regulates the melanization cascade through the specific inhibition of the terminal protease prophenoloxidase-activating enzyme. Our data demonstrate that Serpin-27A is required to restrict the phenoloxidase activity to the site of injury or infection, preventing the insect from excessive melanization. | - |
dc.language | English | - |
dc.title | An immune-responsive Serpin regulates the melanization cascade in Drosophila | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 3 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 581 | - |
dc.relation.lastpage | 592 | - |
dc.relation.journaltitle | Developmental Cell | - |
dc.identifier.doi | 10.1016/S1534-5807(02)00267-8 | - |
dc.identifier.wosid | WOS:000178629300015 | - |
dc.identifier.scopusid | 2-s2.0-18644376155 | - |
dc.author.google | De Gregorio E. | - |
dc.author.google | Han S.-J. | - |
dc.author.google | Lee W.-J. | - |
dc.author.google | Baek M.-J. | - |
dc.author.google | Osaki T. | - |
dc.author.google | Kawabata S.-I. | - |
dc.author.google | Lee B.-L. | - |
dc.author.google | Iwanaga S. | - |
dc.author.google | Lemaitre B. | - |
dc.author.google | Brey P.T. | - |
dc.contributor.scopusid | 이원재(57171092600) | - |
dc.date.modifydate | 20211210153636 | - |