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ACE gene polymorphism and renal scar in children with acute pyelonephritis
- ACE gene polymorphism and renal scar in children with acute pyelonephritis
- Cho S.J.; Lee S.J.
- Ewha Authors
- 이승주; 조수진
- SCOPUS Author ID
- 이승주; 조수진
- Issue Date
- Journal Title
- Pediatric Nephrology
- vol. 17, no. 7, pp. 491 - 495
- SCI; SCIE; SCOPUS
- The pathogenesis of renal scarring after acute pyeloneptritis (APN) in children is multifactorial. In addition to well-known risk factors (young age, high grade of vesicoureteral reflux, P-fimbriated Escherichia coli, and treatment delay), a role for genetic predisposition has been suggested. Since the ACE gene deletion polymorphism is a known risk factor for progressive glomerulosclerosis in chronic renal diseases, we have investigated the relationship between the ACE genotypes and the development of renal scarring after APN. Fifty-nine children (43 males and 16 females) with APN diagnosed by urine culture and technetium-99m-dimercaptosuccinic acid ( 99Tc-DMSA) renal scan were studied. ACE genotypes were determined as II, ID, and DD using the polymerase chain reaction technique. A follow-up 99Tc-DMSA renal scan was performed to evaluate the development of renal scars 3-6 months after treatment. The distribution of ACE genotypes and the allele frequencies were compared in the renal scar-positive (n=39) and -negative group (n=20). ACE genotype frequency after stratification by risk factors was also evaluated. The distribution of ACE genotypes did not differ between the renal scar-positive (II 25.9%, ID 35.9%, DD 28.2%) and -negative group (II 35.0%, ID 45.0%, DD 20.0%), before and after stratification by each risk factor. ACE gene deletion polymorphism did not affect the development of renal scar as an independent variable in children with APN.
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