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dc.contributor.author이승주-
dc.contributor.author조수진-
dc.date.accessioned2017-08-28T10:06:54Z-
dc.date.available2017-08-28T10:06:54Z-
dc.date.issued2002-
dc.identifier.issn0931-041X-
dc.identifier.otherOAK-1159-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/219044-
dc.description.abstractThe pathogenesis of renal scarring after acute pyeloneptritis (APN) in children is multifactorial. In addition to well-known risk factors (young age, high grade of vesicoureteral reflux, P-fimbriated Escherichia coli, and treatment delay), a role for genetic predisposition has been suggested. Since the ACE gene deletion polymorphism is a known risk factor for progressive glomerulosclerosis in chronic renal diseases, we have investigated the relationship between the ACE genotypes and the development of renal scarring after APN. Fifty-nine children (43 males and 16 females) with APN diagnosed by urine culture and technetium-99m-dimercaptosuccinic acid ( 99Tc-DMSA) renal scan were studied. ACE genotypes were determined as II, ID, and DD using the polymerase chain reaction technique. A follow-up 99Tc-DMSA renal scan was performed to evaluate the development of renal scars 3-6 months after treatment. The distribution of ACE genotypes and the allele frequencies were compared in the renal scar-positive (n=39) and -negative group (n=20). ACE genotype frequency after stratification by risk factors was also evaluated. The distribution of ACE genotypes did not differ between the renal scar-positive (II 25.9%, ID 35.9%, DD 28.2%) and -negative group (II 35.0%, ID 45.0%, DD 20.0%), before and after stratification by each risk factor. ACE gene deletion polymorphism did not affect the development of renal scar as an independent variable in children with APN.-
dc.languageEnglish-
dc.titleACE gene polymorphism and renal scar in children with acute pyelonephritis-
dc.typeArticle-
dc.relation.issue7-
dc.relation.volume17-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage491-
dc.relation.lastpage495-
dc.relation.journaltitlePediatric Nephrology-
dc.identifier.doi10.1007/s00467-002-0902-6-
dc.identifier.wosidWOS:000177664300005-
dc.identifier.scopusid2-s2.0-0036952828-
dc.author.googleCho S.J.-
dc.author.googleLee S.J.-
dc.contributor.scopusid이승주(54583939900;7601422007)-
dc.contributor.scopusid조수진(35200321000)-
dc.date.modifydate20180403152730-
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의과대학 > 의학과 > Journal papers
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