Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이승주 | * |
dc.contributor.author | 조수진 | * |
dc.date.accessioned | 2016-08-28T11:08:03Z | - |
dc.date.available | 2016-08-28T11:08:03Z | - |
dc.date.issued | 2002 | * |
dc.identifier.issn | 0931-041X | * |
dc.identifier.other | OAK-1159 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/219044 | - |
dc.description.abstract | The pathogenesis of renal scarring after acute pyeloneptritis (APN) in children is multifactorial. In addition to well-known risk factors (young age, high grade of vesicoureteral reflux, P-fimbriated Escherichia coli, and treatment delay), a role for genetic predisposition has been suggested. Since the ACE gene deletion polymorphism is a known risk factor for progressive glomerulosclerosis in chronic renal diseases, we have investigated the relationship between the ACE genotypes and the development of renal scarring after APN. Fifty-nine children (43 males and 16 females) with APN diagnosed by urine culture and technetium-99m-dimercaptosuccinic acid ( 99Tc-DMSA) renal scan were studied. ACE genotypes were determined as II, ID, and DD using the polymerase chain reaction technique. A follow-up 99Tc-DMSA renal scan was performed to evaluate the development of renal scars 3-6 months after treatment. The distribution of ACE genotypes and the allele frequencies were compared in the renal scar-positive (n=39) and -negative group (n=20). ACE genotype frequency after stratification by risk factors was also evaluated. The distribution of ACE genotypes did not differ between the renal scar-positive (II 25.9%, ID 35.9%, DD 28.2%) and -negative group (II 35.0%, ID 45.0%, DD 20.0%), before and after stratification by each risk factor. ACE gene deletion polymorphism did not affect the development of renal scar as an independent variable in children with APN. | * |
dc.language | English | * |
dc.title | ACE gene polymorphism and renal scar in children with acute pyelonephritis | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 17 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 491 | * |
dc.relation.lastpage | 495 | * |
dc.relation.journaltitle | Pediatric Nephrology | * |
dc.identifier.doi | 10.1007/s00467-002-0902-6 | * |
dc.identifier.wosid | WOS:000177664300005 | * |
dc.identifier.scopusid | 2-s2.0-0036952828 | * |
dc.author.google | Cho S.J. | * |
dc.author.google | Lee S.J. | * |
dc.contributor.scopusid | 이승주(54583939900;57219300715) | * |
dc.contributor.scopusid | 조수진(35200321000) | * |
dc.date.modifydate | 20231120164420 | * |