Synthesis and biological evaluation of novel D-2′-azido-2′,3′-dideoxyarabinofuranosyl-4′- thiopyrimidines and purines

Abstract

Novel D-2′-azido-2′,3′-dideoxyarabinofuranosyl-4′- thiopyrimidines and purines have been synthesized, starting from L-xylose via azidation at the 2′-position as a key step. Most of the final nucleosides exhibited toxicity-dependent anti-HIV-1 activity, among which D-α-adenine analogue 3h was found to be the most cytotoxic. © 2002 Elsevier Science Ltd. All rights reserved.