View : 19 Download: 0

Synthesis and biological evaluation of novel D-2′-azido-2′,3′-dideoxyarabinofuranosyl-4′- thiopyrimidines and purines

Title
Synthesis and biological evaluation of novel D-2′-azido-2′,3′-dideoxyarabinofuranosyl-4′- thiopyrimidines and purines
Authors
Kim H.O.Park Y.H.Moon H.R.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2002
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 12, no. 17, pp. 2403 - 2406
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Novel D-2′-azido-2′,3′-dideoxyarabinofuranosyl-4′- thiopyrimidines and purines have been synthesized, starting from L-xylose via azidation at the 2′-position as a key step. Most of the final nucleosides exhibited toxicity-dependent anti-HIV-1 activity, among which D-α-adenine analogue 3h was found to be the most cytotoxic. © 2002 Elsevier Science Ltd. All rights reserved.
DOI
10.1016/S0960-894X(02)00394-3
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE